Palisaded Neutrophilic and Granulomatous Dermatitis-Like Reaction Associated with Wilms Tumor 1 Protein-Derived Peptide Vaccine: A Case and Review of the Literature

Abstract

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inflammatory cutaneous reaction that is associated with underlying autoimmune diseases. In rare cases, PNGD has been attributed to systemic medications. Here we report one case of a cutaneous injection-site reaction that occurred after intradermal administration of an experimental Wilms Tumor 1 (WT1) protein-derived peptide vaccine in a woman being treated for recurrent ovarian cancer. This is the first reported case of a PNGD-like reaction associated with immunotherapy injections. In this article, we discuss this case and summarize the literature related to the diagnosis and management of PNGD, as well as other injection site reactions related to immunotherapies and experimental vaccines.