Loading-Dose Dupilumab May Function as a Prophylactic Agent for Food-Induced Anaphylaxis: A Case and Review of the Literature
Abstract
Recent advances in targeted therapy using monoclonal antibodies have revolutionized care in many fields, and dupilumab for the treatment of moderate-severe atopic dermatitis is no exception. While on a trial of loading dose dupilumab, a 25-year-old white male with a past medical history significant for anaphylaxis after ingesting peanuts and tree nuts did not experience anaphylaxis after accidentally consuming almonds. Similarly to anti-IgE, the large-scale inhibition of IL-4 and IL-13 signaling to various immune cells involved with type II hypersensitivity reactions using loading dose dupilumab may have played a role in preventing anaphylaxis in this patient. The role of loading dose dupilumab as a potential prophylactic agent against food-induced anaphylaxis could be explored cautiously as a novel way to reduce both morbidity and mortality in patients with these allergies.
Keywords: Allergy, Anaphylaxis, Drug, Prophylaxis, Atopic Dermatitis, Dupixent, dupilumab, Biologic
How to Cite:
Watkins, D., Fredrickson, K., Malerich, P., Watkins, D., Fredrickson, K. & Malerich, P., (2024) “Loading-Dose Dupilumab May Function as a Prophylactic Agent for Food-Induced Anaphylaxis: A Case and Review of the Literature”, Academic Dermatology 2(1), 1-5. doi: https://doi.org/10.18061/ad.v2i1.9666
Rights: Dean E. Watkins, Kaylee Fredrickson, Patricia Malerich
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